New HA products start their life in the R&D laboratory, and with the pressure to meet market demands to get the product out as quickly and efficiently as possible, many small company operated formulation labs might opt for a more flexible semi-automated scale of production. In particular, when it comes to small-scale batch manufacturing, many customers expect flexibility in their semi-automated filling and stoppering equipment.

This is where the Rychiger Pharmatech Z-Lab comes into play. Its filling systems are equipped with easily adjustable settings, allowing for bubble-free filling and stoppering of different formulations and product viscosities. The compact design of the Z-Lab allows for it to fit inside laminar-flow hoods and even isolator containment solutions, all while retaining the same technology and process parameters as their larger cousins that are found in fully automated filling lines.

Figure 1: Z-Lab allows for efficient and high quality small-scale production

When it comes to the production of HA products, the presence of bubbles can pose a large risk as they can lead to the loss of many batches. Recognising this problem, engineers at Rychiger Pharmatech AG focused their efforts on working with customers to ensure reliable and affordable bubble-free mixing and supply of viscous HA.

Once the HA substance has been mixed, It is then fed to the filling line, which uses a vacuum to ensure that no air is reintroduced to the substance. This guarantees no bubbles, and therefore, no potential loss of product. With Rychiger Pharmatech technology, you can extract the maximum possible product and minimise rejects upstream in the filling line, ensuring optimal efficiency and process conditions in the production of your products.

Figure 2: Bubble-free vacuum mixing tank and supply container

Are you looking to scale up your manufacturing process? If yes, then Rychiger Pharmatech has got you covered as well. Our Z-810 PFS filling line is a fully automated filling and closing machine which can process up to 5000/hr using the same bubble-free technology found in other Rychiger Pharmatech models. Whether it be PFS, vials, cartridges, or other formats, the Z-810 can be upgraded or supplied for all Ready-To-Use (RTU) nested formats.

The Z-810 also makes use of robotic handling to manage the different formats and remove the operator from the manufacturing process, further increasing efficiency. This combined with the ability to install gravimetric In-Process Control (IPC) to the filling lines, ensures that the multi-format Z-810 provides maximum flexibility and cost-effectiveness to any manufacturing facility.

Figure 3: The Rychiger Pharmatech Z-810 sterile multi-format filling
and closing machine

This whitepaper was written by Dale Charlton (PhD), an expert in laboratory and production automation, currently working as a consultant for the pharma packaging industry. If you would like to reach out to him personally, you can find his contact information in the figure on the right. If you would like to read more about our solutions for hyaluronic acid, you can click on the button below to be taken to our factsheet on the topic.

Below you will also find links to our product line, as well as contact information. At Rychiger Pharmatech, we are here to provide you with the best possible solutions for your pharma, healthcare, and cosmetic packaging needs, so don’t hesitate to reach out!

Contact us:
sales.rypa@rychiger.com